Cheryl Lee, PhD
Assistant Professor
National University of Singapore
National University of Singapore
NUSMed Infectious Diseases TRP
Department of Microbiology and Immunology
NUSMed Infectious Diseases TRP
Department of Microbiology and Immunology
Immunometabolism is an emerging field that impacts immunological studies cutting across many fields like infectious diseases, cancer, autoimmune diseases etc. Our research group studies how our body’s metabolic pathways shape immune responses during infections. We investigate how mitochondrial metabolism like respiration, lipid and amino acid catabolism regulate specific leukocyte functions. This approach provides critical insight into why immune responses are often dysregulated in patients with metabolic diseases such as diabetes, who face poorer outcomes during infections.
To drive these discoveries, we leverage cutting-edge technologies including single-cell RNA sequencing (scRNA-seq), advanced metabolomics, metabolic quantification platforms, and high-throughput flow cytometry. Through this multidisciplinary strategy, we aim to uncover novel metabolic pathways that govern immune activation and pave the way for innovative therapies to improve patient health.
Research Themes
Understanding how changes to the electron transport chain during leukocye activation modulate leukocyte functions
Identifying novel metabolic regulators of leukocyte activation using high throughput assays like CRISPR screens, scRNA-seq and drug screens
Determining how metabolic pathways controlling immune response are dysregulated in patients with metabolic disorders, resulting in poorer outcomes during infections
We are currently recruiting PhD, MSc and BSc students. Any motivated prospective candidates, please contact Cheryl.