Publications

Mitochondrial Chaperon TNF-Receptor-Associated Protein 1 as Novel Immune-Regulator in Pneumocystis jirovecii Pneumonia

Aseervatham Anusha Amali, Kathirvel Paramasivam, Chiung Hui Huang, Abhinav Joshi, Jayshree L. Hirpara, Sharada Ravikumar, Qi Hui Sam, Rachel Ying Min Tan, Zhaohong Tan, Dilip Kumar, Leonard M. Neckers, Shazib Pervaiz, Roger Foo, Candice Chan, Jing Zhu, Cheryl QE Lee*, Louis Yi Ann Chai*. 2024. Frontiers in Immunology. *Co-last authors

Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19

Janessa Y.J. Tan, Danielle E. Anderson, Abhay P.S. Rathore, Aled O’Neill, Chinmay Kumar Mantri, Wilfried A.A. Saron, Cheryl Q.E. Lee, Chu Wern Cui, Adrian E.Z. Kang, Randy Foo, Shirin Kalimuddin, Jenny G. Low, Lena Ho, Paul Tambyah, Thomas W. Burke, Christopher W. Woods, Kuan Rong Chan,1 Jörn Karhausen, and Ashley L. St. John. 2023. Journal of Clinical Investigation; 133(19):e149834.

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

*Rhea Nadkarni, *Werncui Chu, *Cheryl QE Lee, Yasir Mohamud, Lynn Yap, Gee Ann Toh, Sheryl Beh, Radiance Lim, Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Kim Robinson, Karl Tryggvason, Honglin Luo, Franklin Zhong, and Lena Ho. 2022. Journal of Experimental Medicine; 219 (10): e20212117. * co-first authors.

A high-resolution map of human RNA translation

Sonia P Chothani, Eleonora Adami, Anissa A Widjaja, Sarah R Langley, Sivakumar Viswanathan, Chee Jian Pua, Nevin Tham Zhihao, Nathan Harmston, Giuseppe D'Agostino, Nicola Whiffin, Wang Mao, John F Ouyang, Wei Wen Lim, Shiqi Lim, Cheryl Q E Lee, Alexandra Grubman, Joseph Chen, J P Kovalik, Karl Tryggvason, Jose M Polo, Lena Ho, Stuart A Cook, Owen J L Rackham, Sebastian Schafer. 2022. Molecular Cell. Aug 4;82(15):2885-2899.e8.

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

Cheryl QE Lee, Baptiste Kerouanton, Sonia Chothani, Shan Zhang, Ying Chen, Chinmay Kumar Mantri, Daniella Helena Hock, Radiance Lim, Rhea Nadkarni, Vinh Thang Huynh, Daryl Lim, Wei Leong Chew, Franklin L. Zhong, David Arthur Stroud, Sebastian Schafer, Vinay Tergaonkar, Ashley L. St John, Owen J. L. Rackham & Lena Ho. 2021. Nature Communications. 12, 2130.

Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy.

Hui Hui Wong, Sze Hwee Seet, Michael Maier, Ayse Gurel, Ricardo Moreno Traspas, Cheryl QE Lee, Shan Zhang, Beril Talim, Abigail Y T Loh, Crystal Y Chia, Tze Shin Teoh, Danielle Sng, Jarred Rensvold, Sule Unal, Evgenia Shishkova, Ece Cepni, Fatima M Nathan, Fernanda L Sirota, Chao Liang, Nese Yarali, Pelin O Simsek-Kiper, Tadahiro Mitani, Serdar Ceylaner, Ozlem Arman-Bilir, Hamdi Mbarek, Fatma Gumruk, Stephanie Efthymiou, Deniz Uğurlu Çi Men, Danai Georgiadou, Kortessa Sotiropoulou, Henry Houlden, Franziska Paul, Davut Pehlivan, Candice Lainé, Guoliang Chai, Nur Ain Ali, Siew Chin Choo, Soh Sok Keng, Bertrand Boisson, Elanur Yılmaz, Shifeng Xue, Joshua J Coon, Thanh Thao Nguyen Ly, Naser Gilani, Dana Hasbini, Hulya Kayserili, Maha S Zaki, Robert J Isfort, Natalia Ordonez, Kornelia Tripolszki, Peter Bauer, Nima Rezaei, Simin Seyedpour, Ghamar Taj Khotaei, Charles C Bascom, Reza Maroofian, Myriam Chaabouni, Afaf Alsubhi, Wafaa Eyaid, Sedat Işıkay, Joseph G Gleeson, James R Lupski, Jean-Laurent Casanova, David J Pagliarini, Nurten A Akarsu, Sebastian Maurer-Stroh, Arda Cetinkaya, Aida Bertoli-Avella, Ajay S Mathuru, Lena Ho, Frederic A Bard , Bruno Reversade. 2021. American Journal of Human Genetics, 108(7), 1301–1317.

Inhibition of phosphoinositide-3-kinase signaling promotes the stem cell state of trophoblast

Cheryl QE Lee, Alexander Bailey, Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri, Klaus Okkenhaug, Ashley Moffett, Janet Rossant, and Myriam Hemberger. 2019. STEM CELLS 37 (10): 1307–18.

Esrrb Function Is Required for Proper Primordial Germ Cell Development in Presomite Stage Mouse Embryos

Eiichi Okamura, Oliver H. Tam, Eszter Posfai, Lingyu Li, Katie Cockburn, Cheryl QE Lee, Jodi Garner, and Janet Rossant. 2019. Developmental Biology 455 (2): 382–92.

Integrin Α2 Marks a Niche of Trophoblast Progenitor Cells in First Trimester Human Placenta

Cheryl QE Lee, Margherita Y. Turco, Lucy Gardner, Benjamin D. Simons, Myriam Hemberger, and Ashley Moffett. 2018. Development (Cambridge) 145 (16).

IFPA meeting 2016 workshop report II: Placental imaging, placenta and development of other organs, sexual dimorphism in placental function and trophoblast cell lines

Jennifer Adibi, Graham J. Burton, Vicki Clifton, Sally Collins, Antonio E. Frias, Lobke Gierman, Peta Grigsby, Helen Jones, Cheryl QE Lee, Alina Maloyan, et al. 2017. Placenta. pii: S0143-4004(17)30174-1

What is trophoblast? A combination of criteria define human first trimester trophoblast

Cheryl QE Lee, Lucy Gardner, Margherita Turco, Nancy Zhao, Matthew J Murray, Nicholas Coleman, Janet Rossant, Myriam Hemberger, Ashley Moffett. 2016. Stem Cell Reports. 6(2):257-72